Registration Dossier
Registration Dossier
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EC number: 200-606-7 | CAS number: 65-30-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Natural Products for Insect Pest Management
- Author:
- E.A.BUSS et.al
- Year:
- 2 016
- Bibliographic source:
- Institute of Food and Agricultural Sciences (IFAS), 2016
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity LD50
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012.
- Reference Type:
- other: authoritative database
- Title:
- Acute Oral Toxicity of test chemical.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced
- Reference Type:
- other: authorative database
- Title:
- GESTIS Substance Database for test chemical
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- IFA GESTIS; 2017
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study conducted by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 015
- Bibliographic source:
- HSDB
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity of Nicotine sulphate
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS
- Reference Type:
- secondary source
- Title:
- Toxicity Effects: Nicotine sulphate
- Author:
- National Toxicology Program
- Year:
- 2 015
- Bibliographic source:
- National Toxicology Program
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity - CAS no: 65-30-5
- Author:
- Peshin et al.
- Year:
- 2 009
- Bibliographic source:
- Integrated Pest Management
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of the test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Nicotine sulphate
- EC Number:
- 200-606-7
- EC Name:
- Nicotine sulphate
- Cas Number:
- 65-30-5
- Molecular formula:
- C10H14N2.1/2H2O4S
- IUPAC Name:
- 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid
- Details on test material:
- - IUPAC Name: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid
- Common Name: Nicotine sulphate
- InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;
(H2,1,2,3,4)/t2*10-;/m00./s1
- Smiles: CN1CCC[C@H]1c2cccnc2.CN3CCC [C@H]3c4cccnc4.OS(=O)(=O)O
- Molecular formula:C10H16N2O4S
- Molecular weight :422.547 g/mol
- Substance type:Organic
- Physical state:Solid, white brown crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 50 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 50 mg/kgbw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 value was considered to be 50 mg/kg bw, when rats were treated with the test chemical via oral route.
- Executive summary:
Acute oral toxicity study of the test chemical was conducted in rats at the dose concentration of 50 mg/kg bw. 50% mortality was observed. Hence, LD50 value was considered to be 50 mg/kg bw, whenrats were treated with the test chemical via oral route.
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