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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from handbook.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acute oral toxicity LD50
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012.
Reference Type:
other: authoritative database
Title:
Acute Oral Toxicity of test chemical.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced
Reference Type:
other: authorative database
Title:
GESTIS Substance Database for test chemical
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
IFA GESTIS; 2017
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study conducted by using test chemical
Author:
U.S. National Library of Medicine
Year:
2015
Bibliographic source:
HSDB
Reference Type:
secondary source
Title:
Acute oral toxicity of Nicotine sulphate
Author:
RTECS
Year:
2017
Bibliographic source:
RTECS
Reference Type:
secondary source
Title:
Toxicity Effects: Nicotine sulphate
Author:
National Toxicology Program
Year:
2015
Bibliographic source:
National Toxicology Program
Reference Type:
review article or handbook
Title:
Acute oral toxicity - CAS no: 65-30-5
Author:
Peshin et al.
Year:
2009
Bibliographic source:
Integrated Pest Management

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid (CAS no: 65-30-5) in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid
- Common Name: Nicotine sulphate
- InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;
(H2,1,2,3,4)/t2*10-;/m00./s1
- Smiles: CN1CCC[C@H]1c2cccnc2.CN3CCC [C@H]3c4cccnc4.OS(=O)(=O)O
- Molecular formula:C10H16N2O4S
- Molecular weight :422.547 g/mol
- Substance type:Organic
- Physical state:Solid, white brown crystalline
Specific details on test material used for the study:
- IUPAC Name: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid
- Common Name: Nicotine sulphate
- InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;
(H2,1,2,3,4)/t2*10-;/m00./s1
- Smiles: CN1CCC[C@H]1c2cccnc2.CN3CCC [C@H]3c4cccnc4.OS(=O)(=O)O
- Molecular formula:C10H16N2O4S
- Molecular weight :422.547 g/mol
- Substance type:Organic
- Physical state:Solid, white brown crystalline

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
50 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
50 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
The acute oral LD50 value was considered to be 50 mg/kg bw, when rats were treated with 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid (CAS no: 65-30-5) via oral route.
Executive summary:

Acute oral toxicity study of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid (CAS no: 65-30-5) was conducted in rats at the dose concentration of 50 mg/kg bw. 50% mortality was observed. Hence, LD50 value was considered to be 50 mg/kg bw, whenrats were treated with3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; sulfuric acid via oral route.