Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on absorption rate using the closely related substance MEA polyborate (EC 247-421-8): 
Rat, mouse, rabbit and human skin were administered nominal doses of 4 mg/cm² of undiluted or aqueous MEA in vitro.  Mean dermal absorption values after 6 hours were 5.98,16.92, 8.66 and 0.61% (undiluted MEA) and 1.32, 24.79, 1.87 and 1.11% (aqueous MEA), respectively for rat, mouse, rabbit and human skin. It is appropriate to utilise the highest dermal absorption value for human skin to be conservative in risk assessment. Therefore, a dermal absorption value of 1.11% in aqueous MEA has been identified for human skin.

Key value for chemical safety assessment

Absorption rate - dermal (%):
1.1

Additional information