Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 701-196-7 | CAS number: -
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022 (please refer to attached justification)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- study ongoing
- Justification for type of information:
- In the Final Decision on a Testing Proposal dated 10 December 2018, ECHA requested to submit a Pre-natal developmental toxicity study (Annex IX, Section 8.7.2.; test method: OECD TG 414) in a first species (rat or rabbit) via oral route and an Extended one-generation reproductive toxicity study (Annex IX, Section 8.7.3.; test method: OECD TG 443) in rats via oral route with the registered substance by 17 June 2021. However, due to several reasons as lined out in the letter from the performing laboratory, the experimental phase of these studies has been delayed.
Please refer to the attached documents for further details regarding the request of the ECHA Final Decision.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
- EC Number:
- 701-196-7
- Cas Number:
- 72244-98-5
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- Details will be added as soon as available.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: to be determined
- Details on exposure:
- Details will be added as soon as available.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Details will be added as soon as available.
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- other: to be determined
- Remarks on result:
- other: to be determined
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- other: to be determined
- Remarks on result:
- other: to be determined
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- to be determined
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
