2-ethylhexyl diphenyl phosphate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

January, 1971

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was not conducted according to an existing OECD guideline, and no data on GLP, but acceptable basic information.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The undiluted compound was dosed by intraperitoneal injection to Swiss-Webster strain albino male and female mice. After the approximate Minimum Lethal Dose was determined, groups of mice equally divided as to sex were dosed in increasing doses at increments of 0.l fractional log intervals at 4 levels (631, 794, 1000, and 1260 mg/kg) designed to blanket the toxicity range, thereby supplying data for calculation of the LD50 which was done according to the method of E. J. de Beer. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl diphenyl phosphate

EC Number:

214-987-2

EC Name:

2-ethylhexyl diphenyl phosphate

Cas Number:

1241-94-7

Molecular formula:

C20H27O4P

IUPAC Name:

2-ethylhexyl diphenyl phosphate

Details on test material:

- Name of test material (as cited in study report): Santicizer 141

Test animals

Species:

mouse

Strain:

Swiss Webster

Sex:

male/female

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

unchanged (no vehicle)

Doses:

631, 794, 1000, and 1260 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 930 mg/kg bw

Remarks on result:

other: Mice; Lower and upper limits 850 and 1020 mg/kg respectively

Any other information on results incl. tables

Survival time was 1 to 5 days with most deaths occurring within 3 days. Toxic signs included reduced appetite and activity, lethargy, increasing weakness, slight tremors, collapse, and death. At autopsy there was lung hypomania, slight liver discoloration, and gastrointestinal inflammation at area of infection. Surviving animals were sacrificed 7 days after dosing. The viscera appeared normal by macroscopic examination.

Applicant's summary and conclusion

Conclusions:

The intraperitoneal LD50 for male and female mice was placed at 930 mg/kg with lower and upper limits of 850 to 1020 mg/kg. Santicizer 141 does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008 (CLP/EU-GHS).

Executive summary:

The acute inhalation toxicity of Santicizer 141 towards mice was investigated. The undiluted compound was dosed by intraperitoneal injection to Swiss-Webster strain albino male and female mice. After the approximate Minimum Lethal Dose was determined, groups of mice equally divided as to sex were dosed in increasing doses at increments of 0.l fractional log intervals at 4 levels (631, 794, 1000, and 1260 mg/kg) designed to blanket the toxicity range, thereby supplying data for calculation of the LD50 which was done according to the method of E. J. de Beer. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. Survival time was 1 to 5 days with most deaths occurring within 3 days. Toxic signs included reduced appetite and activity, lethargy, increasing weakness, slight tremors, collapse, and death. At autopsy there was lung hypomania, slight liver discoloration, and gastrointestinal inflammation at area of infection. Surviving animals were sacrificed 7 days after dosing. The viscera appeared normal by macroscopic examination. The intraperitoneal LD50 for male and female mice was placed at 930 mg/kg with lower and upper limits of 850 to 1020 mg/kg. Santicizer 141 does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008 (CLP/EU-GHS).