Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

DEAE was evaluated for dermal sensitization in 20 female Hartley guinea pigs by maximization test similar to OECD guideline 406 (Leung 1998; Val. 2). For induction, the animals were given intradermal injections into 2 sites each of clipped shoulder skin followed by a 48 h epicutaneous application 7 days later. Epicutanous challenge was performed by a 24 h patch at 14 days after induction to a previous untreated site. None of the animals treated with the test substance (0/20) exhibited skin responses. All 10 positive control animals challenged with DCNB showed a clear response.

In a second study the induction was made via intradermal injection of 10000 ppm and topical treatment with a 50000 ppm solution in olive oil (Nakamura 1994; Val. 2). Twenty-one days after the initial intradermal injection, 0,1 ml aliquots of various non-irritation concentrations of DEAE were applied in saline for challenge (0, 1250, 2500, 5000, 10000 ppm). Sensitisation was not observed in any of the DEAE-challenged animals.

In an older study ten guinea pigs were used and inducted with intradermal injections of 0.1% aqueous solutions every other day for a total of 10 doses (Pennwalt 1958; Val. 2). 14 days after the last application the animals were challenged with a single intradermal injection of a 0.1% aqueous solution. 24 hours after challenge injection the skin sensitization was evaluated. According to the authors, the test substance was not a sensitizer in this study. Zero out of 10 animals responded to DEAE.

Thus, taking all 3 studies into consideration, none of the 2 -diethylaminoethanol-induced animals showed signs of sensitization after challenge.


Migrated from Short description of key information:
not sensitising

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
no data available concerning respiratory sensitising potential

Justification for classification or non-classification

EU classification according to Annex I of Directive 67/548/EEC: none

EU classification according to EC/1272/2008 (CLP): none