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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary quotation with some essential details missing. However, source and authors are acknowledged and thus, the data are considered suitable for assessment of the acute dermal toxicity risk.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unpublished data from personal communication given through a member of the TLV Committee (November 1964).
Author:
Smyth, HF, Jr.
Year:
1980
Bibliographic source:
Cited in: Documentation of the Threshold Limit Values and Biological Exposure Indices, 2-Diethylaminoethanol, pp. 140-141.
Reference Type:
other: US EPA TSCA 8(e) submission
Title:
Unnamed
Year:
1942
Report Date:
1942
Reference Type:
publication
Title:
2-DIETHYLAMINOETHANOL CAS N°:100-37-8, SIDS Initial Assessment Report For SIAM 15
Author:
OECD SIDS
Year:
2004
Bibliographic source:
UNEP Publication

Materials and methods

Principles of method if other than guideline:
The study was conducted prior to the implementation of current testing guidelines.
GLP compliance:
no
Remarks:
GLP was not compulsory at the time the study was conducted
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-diethylaminoethanol
- Analytical purity: not indicated

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 100 mg/kg bw
Remarks on result:
other: original value: 1.26 mL/kg bw

Applicant's summary and conclusion