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Short-term toxicity to aquatic invertebrates

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Description of key information

With high probability acutely not harmful to aquatic invertebrates.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
165 mg/L

Additional information

The short-term toxicity of 2-diethylaminoethanol to aquatic invertebrates was investigated in a study according to EU Method C.2 (BASF AG, 1988). Based on nominal test concentrations the 48-h EC50 was determined to be 83.6 mg/L; the test solutions were not neutralized in this study.

 

The nominal concentrations were 0 (control), 7.81, 15.6, 31.2, 62.5, 125, 250, and 500 mg/l; they were not analytically verified, but are assumed to be stable due to the the low n-octanol/water partition coefficient (log Kow = 0.21), the high water solubility (WS = 1.0E+06 mg/L at 23 °C), the moderate vapour pressure (VP = 2 hPa, at 22.4 °C) and the low Henry´s law constant (HLC, uncharged: 3.17E-04 Pa*m³/mol) of the chemical. Furthermore, the substance was found to be stable during a test on short-term toxicity to fish conducted according to APHA (1980) standard methods for the examination of water and waste water which are similar to OECD 203 testing guideline (Geiger et al., 1986).

 

In addition, a further test on short-term toxicity to aquatic invertebrates according to OECD 202 (Atofina, 1993) showed an acceptable recovery of the test item in the test solutions. Based on nominal concentrations, the 48-h EC50 was 165 mg/L. 

 

With regard to the EC50, the effect values show a significantly higher toxicity using non-neutralized test solutions; therefore, the observed toxicity is partly due to the pH induced by the substance. For risk assessment the effect data for the neutralized test medium should be used, since the quantities of 2-diethylaminoethanol that would be found in natural waters are not likely to affect the pH to a relevant extend. It is likely that the EC50 value from the test without neutralization overestimates the potential toxicity of the target item.

 

Based on the data for neutralized test solutions (48-h EC50 = 165 mg/L), the substance is assessed to be with high probability not harmful to aquatic invertebrates.