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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication/study report which meets basic scientific principles

Data source

Reference
Title:
No information
Author:
Smith, M.A., Gandy, J. (1990): Air Force Office of|Scientific Research report No. 90 0684, NTIS/AD-7224022

Materials and methods

Type of study / information:
Type: other: Acute toxicity
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single intraperitoneal administration of different concentrations of chlorobenzene (0.01 - 1.0 mL/kg bw ) to male mice  in order to evaluate the effect
on the concentration of hepatic glutathione.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

After a single i.p. administration of 0.01 - 1.0 ml chloro-
benzene/kg bw (11 - 1106 mg/kg bw) to male B6C3F1 mice the
hepatic glutathione concentration was significantly
decreased at doses >= 0.1 ml/kg at 3 h post-treatment and the
serum alanine aminotransferase activity was significantly
increased at doses >= 0.5 ml/kg at 48 h posttreatment. A
dose of 1.0 ml/kg was lethal.

Applicant's summary and conclusion