Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-01-15 to 2016-02-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.36
Temp.:
25 °C
pH:
6.68
Details on results:
The determined log Pow: 1.36 ± 0.005 (95 % confidence interval).
Quality criteria were met as values of log P derived from individual measurements fell within a range of 0.1 log units.

Table 1 Measured and calculated data of test item

 

Retention time (min)

Log k

LogPow

Pow

Repeatability log unit

 

 

calculated

Test item

3.98

-0.261

1.36

23

0.01

 

3.99

-0.258

1.37

23

 

3.98

-0.261

1.36

23

 

3.99

-0.258

1.37

23

 

3.98

-0.261

1.36

23

 

3.98

-0.261

1.36

23

Mean

3.98

-0.261

1.36

23

-

Conf. Int. (95%)

0.01

-

0.005

0.3

-

CV %

-

-

-

-

-

Conclusions:
The log Pow of the test substance was determined as 1.36 ± 0.005.
Executive summary:

The purpose of this study was to determine the partition coefficient of the test item using HPLC method according to EU Method A.8, OECD 117, and OPPTS 830.7570. In the course of this study the partition coefficient (Pow) of the test item was determined using high performance liquid chromatography. The log Pow of the test substance was determined as 1.36 ± 0.005.

Description of key information

The log Pow of the test substance was determined as 1.36 ± 0.005.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.36
at the temperature of:
25 °C

Additional information

The purpose of this study was to determine the partition coefficient of the test item using HPLC method according to EU Method A.8, OECD 117, and OPPTS 830.7570. In the course of this study the partition coefficient (Pow) of SIKA Aldehyde A was determined using high performance liquid chromatography. The log Pow of the test substance was determined as 1.36 ± 0.005.