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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-04-24 to 2017-11-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
static method
Specific details on test material used for the study:
Batch no.: I1400986-MG-06-050.6_MG-06-087.1
Purity: 98.4 %
Key result
Temp.:
20 °C
Vapour pressure:
106 Pa
Temp.:
25 °C
Vapour pressure:
147 Pa

Table 1. Measured values

1st Determination
increasing temperature

2nd Determination
decreasing temperature

Temp. in °C

Pressure in hPa

Temp. in °C

Pressure in hPa

20.0

1.1

52.9

7.6

27.0

1.7

43.1

4.4

35.0

2.7

34.1

2.7

43.8

4.6

26.0

1.6

51.6

6.9

20.0

1.0

59.9

10.9

16.0

0.8

Calculation of results

From the measured values for the increasing and for the decreasing temperature, log P (in log Pa) and 1/T (in 1/K) were calculated. The measured and the calculated values were plotted (p against T and log P against 1/T).

The regression curve with slope B, intercept A and correlation r was calculated (graph log P vs. 1/T). From the values of these parameters, vapour pressures at 20.0 and at 25.0 °C were calculated using the following equation:

log P = B*1/T+A

where B = -2477.989935 and A = 10.47927829

Table 2. Calculated parameters

n

Temperature T

Pressure P

Temperature T

1/T

log P

 

°C

hPa

K

1/K

log Pa

1

20.0

1.1

293.15

0.00341122

2.0414

2

27.0

1.7

300.15

0.00333167

2.2304

3

35.0

2.7

308.15

0.00324517

2.4314

4

43.8

4.6

316.95

0.00315507

2.6628

5

51.6

6.9

324.75

0.00307929

2.8388

6

59.9

10.9

333.05

0.00300255

3.0374

7

52.9

7.6

326.05

0.00306701

2.8808

8

43.1

4.4

316.25

0.00316206

2.6435

9

34.1

2.7

307.25

0.00325468

2.4314

10

26.0

1.6

299.15

0.00334280

2.2041

11

20.0

1.0

293.15

0.00341122

2.0000

12

16.0

0.8

289.15

0.00345841

1.9031

The calculated values at 20 and 25 were as follows:

Table 3. Calculated vapour pressure at 20 and 25 °C.

Parameter

Value

Unit

Vapour Pressure (20 °C)

106

Pa

Vapour Pressure (25 °C)

147

Pa

Conclusions:
The vapour pressure of the test item was calculated to be 106 Pa at 20 °C and 147 Pa at 25 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at six different temperatures (20, 27, 35, 43.8, 51.6 and 59.9 °C) using the static method. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 106 Pa at 20 °C and 147 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was calculated to be 106 Pa at 20 °C and 147 Pa at 25 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
106 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at six different temperatures (20, 27, 35, 43.8, 51.6 and 59.9 °C) using the static method. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 106 Pa at 20 °C and 147 Pa at 25 °C, respectively.