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EC number: 500-045-0 | CAS number: 26027-38-3 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). Effect concentration i.e EC50 value was estimated to be 1.43 mg/l for Daphnia magna for 24 hrs duration. It was concluded that the 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) was likely to be toxic to aquatic invertebrates, hence it can be considered to be classified as per the CLP classification criteria for aquatic environment.
Toxicity to aquatic algae and cyanobacteria
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the toxicity to algae was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). Effect concentration i.e EC50 value was estimated to be 4.29 mg/l for Daphnia magna for 72 hrs duration. It was concluded that the 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) was likely to be toxic to algae, hence it can be considered to be classified as per the CLP classification criteria for aquatic environment.
Additional information
Short-term toxicity to aquatic invertebrates
Four studies including predicted data from validated tools and experimental data from peer reviewedjournal and authorative database for short term aquatic invertebrate’s endpoint of test chemical 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the sixclosest read across substances, which indicate the short term toxicity on aquatic invertebrates was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) and the Effect concentration i.e EC50 value was estimated to be 1.43 mg/l for Daphnia magna for 48 hrs duration.
Similar prediction by Danish (Q)SAR Database, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of Danish (Q)SAR Database, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 2.40 mg/l for4-Nonylphenol, ethoxylatedin 48 hrs.
Above both predicted results of target assist by experimental result of read across chemical 4-Nonylphenol, ethoxylated (Cas no. 9016-45-9) from peer reviewed journal Environmental Toxicology and Chemistry 2821-2829, 2001 which suggest the 48 h toxicity test of test chemical Nonylphenol, ethoxylated (Cas no 9016-45-9) with Daphnia magna were conducted in accordance with the recommended procedure outlined in U.S. EPA (2002). In experiment the Effective concentration to 50% of test organisms (EC50) on the basis of immobility effect was observed to be 2.8 mg/l 48 hrs exposure period for test chemical 4-Nonylphenol, ethoxylated (Cas no9016-45-9).
Another supporting study for read acrossDodecan-1-ol, ethoxylated(Cas no.9002-92-0) from peer reviewed journalEnvironmental Technology, 11(12): 1143-1146, 1990indicates short term toxicity to aquatic invertebrates was performed inGammarus italicusfor 24 hrs. Test in fresh water media with static condition. During the experiment, the EC50 value forDodecan-1-ol, ethoxylated(Cas no.9002-92-0) was determined to be 9.45 mg/l on the basis of mortality effect.
Thus based on the all available effect concentrations which is in the range of 1.43 mg/l to 9.45 mg/l for target and read across chemicals which come to the conclusion that test substance 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)was likely to be non toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.
Toxicity to aquatic algae and cyanobacteria
Two studies including predicted data from validated tools and experimental data from secondary source
for toxicity to aquatic algae endpoint of test chemical4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) with relevant read across which is close to target using log Kow as primary descriptor were
summarised as follows:
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five
closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). EC50 value was estimated to be 4.29 mg/l for Pseudokirchneriella subcapitata for 72 h duration.
Predicted result for target supported by experimental data of read across chemical4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)from robust summary of the IUCLID DATASET,ICI Internal Report BL4737/B1993 method the effect concentation (EC50) of substance4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)in test speciesSkeletonema costatumwas observed to be2.5 mg/l on the basis of Growth Rate effect for 72 hrs exposure period.
Thus based on the effect concentrations which is in the range 2.5 mg/l to 4.29 give the conclusion that test substance4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)was likely to be non toxic to aquatic algae at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.
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