Registration Dossier
Registration Dossier
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EC number: 224-081-9 | CAS number: 4196-89-8
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity to fish:
No toxic effects 2,2-dimethylpropan-1,3-diyl dibenzoate against fish were observed at the limit of water solubility under exposure conditions. The toxicity to fish was determined at LC50 of >0.280 mg/L after 96 hours. All results are expressed in terms of geometric mean measured concentrations.
Acute toxicity to daphnia:
After 48 hours an EC50 of higher than 0.90 mg/l was measured. No toxic effects of 2,2-dimethylpropan-1,3-diyl dibenzoate against Daphnia were observed at a limit of water solubility under exposure conditions. The results are expressed in terms of geometric mean measured concentrations.
Toxicity to freshwater algae:
In a weight-of-evidence approach it could be shown that 2,2-dimethylpropane-1,3-diyl dibenzoate as such does not cause effects to algae.
Effects observed in one study relate to the main by-product 3-hydroxy-2,2-dimethylpropyl benzoate that was unintentionally enriched during test solution preparation due to its high water solubility.
In a study with purified test item no effects to algae were observed up to the limit of the water solubility.
Toxicity to microorganisms:
After three hours 2,2-dimethylpropan-1,3-diyl dibenzoate showed 5% respiration inhibition of activated sludge at a test item concentration of 1000 mg/L. The EC50 value of higher than 1000 mg/L and the NOEC equal or higher than 1000 mg/L were determined. The effect values relate to a nominal concentration.
All toxicity studies mentioned above are classified as acceptable and satisfy the guideline requirements for the toxicity studies on acute toxicity to aquatic organisms.
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