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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
34 g/L
Temp.:
20 °C
pH:
>= 8.7 - <= 8.9
Remarks on result:
other: It is evident from the chromatography that a small amount of oxidation had occured even though precautions to minimise oxygen were taken.

Results

Preliminary test:

The preliminary estimate of water solubility was 36.9 g/L at 20.0°C.

Definitive test :

Mean peak areas relating to standard and sample solutions

Solution

Mean peak area

Standard 251 mg/l

3.754 X 105

Standard 251 mg/l

3.620 X 105

Sample 1A

2.590 X 105

Sample 1B

2.571 X 105

Sample 2A

2.372 X 105

Sample 2B

2.490 X 105

Sample 3A

2.438 X 105

Sample 3B

2.531 X 105

Concentration (g/l) of test material in the sample solutions

Sample number

Time shaken at 30°C (hours)

 

Time equilibrated at 20°C (hours)

 

Concentration (g/l)

Solution pH

1

24.25

24

35.1

8.9

2

48.25

24

33.1

8.9

3

72.25

24

33.8

8.7

Mean concentration : 34.0g/l at 20 ± 0.5 ºC

Range : 33.1 to 35.1 g/l

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test item has been determined to be 34.0g/l at 20 ± 0.5°C
Executive summary:

Method

The determination was carried out using the flask method designed to be compatible with Method A6 Water Solubility of Commission Directive 92/69/EEC.

Conclusion

The water solubility of the test item has been determined to be 34.0 g/l at 20 ± 0.5 °C.

Description of key information

The water solubility of the test item has been deterimed to be 34.0g/l at 20 ± 0.5°C

Key value for chemical safety assessment

Water solubility:
34 g/L
at the temperature of:
20 °C

Additional information

Method

The determination was carried out using the flask method designed to be compatible with Method A6 Water Solubility of Commission Directive 92/69/EEC.

Conclusion

The water solubility of the test item has been determined to be 34.0 g/l at 20 ± 0.5 °C.