Registration Dossier
Registration Dossier
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EC number: 908-918-1 | CAS number: -
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Studien über den Einfluss technisch wichtiger Gase und Dämpfe auf den Organismus (XXXII/XXXIII) (Experiments about the effects of technically important gases and vapour on the organism)
- Author:
- K.B. Lehmann
- Year:
- 1 913
- Bibliographic source:
- Arch Hyg 78: 260-.273
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- 60g (80ml) Amylacetate were heated in a room of 12m³ effused, and left to evaporize. The final concentration was 5mg/L. Two volunteers stayed in the chamber for 30min.
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- no data
Constituent 1
Method
- Subjects:
- 2 healthy young doctors
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Details on exposure:
- 60g (80ml) Amylacetate were heated in a room of 12m³ effused, and left to evaporize. The final concentration was 5mg/L.
Duration: 30 min
Results and discussion
- Clinical signs:
- At the beginning, irritation of the throat, subsequent coughing.
Later: eye irritation, secretions of the nose. The coughing subsided and was replaced by a dry feeling in the throat.
Pulse normal, no headaches, subjects were slightly tired.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
