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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
other: Analytical Expert Group of ETAD
Version / remarks:
method for substances with very low solubilty in both water and n-octanol
Principles of method if other than guideline:
Determination of solubility in n-octanol and calculation of log Pow with water solubility
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
124.5
Temp.:
23 °C
pH:
ca. 7
Type:
log Pow
Partition coefficient:
2.1
Temp.:
23 °C
pH:
ca. 7
Details on results:
Pow and log Pow were calculated from equilibrium concentrations in n-octanol (see below) and in water (see section 4.8)

The solubility in n-octanol was determined to be 49.8 µg/L at ambient temperature (23-24°C). This figure represents the mean of 5 determinations (range: 45.49-54.56 µg/L, sigma = 3.9). The solubility in water was determined to be 0.4 µg/L (section 4.8)

These solubilities (equilibrium concentrations considering the tests performed) are used to calculate Pow with the following equation:

Pow = equilibrium concentration in n-octanol / equilibrium concentration in water

Pow = 49.8 µg/L / 0.4 µg/L

Pow = 124.5

log Pow = 2.1

Conclusions:
The test substance has a log pow of 2.1.
Executive summary:

The log pow of the test substance was calculated from the equilibrium concentrations in water and in n-octanol. The log pow at 24 °C (24 -25 °C for water, 23 -24 °C for n-octanol) was 2.1.

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
2.1
at the temperature of:
23 °C

Additional information