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Dodecamethylcyclohexasiloxane (D6) is a liquid at standard temperature and pressure, with a melting point of -3°C at 1013 hPa, and a boiling point of 245°C at 1013 hPa. It has a density slightly less than that of water (0.98 g/cm3 at 20°C) and a kinematic viscosity value of 5.6 mm2/s at 20°C. It has a predicted vapour pressure of 4.7 Pa at 25°C.

The substance is not classified for flammability on the basis of a measured flash point of 91°C at 1013 hPa and boiling point of 245°C at 1013 hPa in accordance with Regulation (EC) No. 1272/2008. D6 has a measured autoignition temperature of 368-371°C at 1013 hPa and it is not explosive and not oxidising on the basis of structural examination.

In contact with water, D6 will hydrolyse very slowly with a hydrolysis half-life of 42 h at pH 4, approximately 9600 h (401 days) at pH 7 and 125 h at pH 9 and 25°C. The product of hydrolysis is dimethylsilanediol. .

[-Si(CH3)2O-]6+ 6H2O → 6(CH3)2Si(OH)2

D6 has low water solubility of approximately 5 µg/l at 23°C, and a high log Kow of 8.87. Based on an examination of the chemical structure, the substance is not expected to dissocite under relevant environmental conditions. Further testing for water-based physicochemical properties is waived due to the low solubility.