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Immunotoxicity

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Description of key information

Exposure to up to 500 ppm ethyl benzene vapour for 28-d did not affect the humoral component of the rat immune system.

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Additional information

The potential impact of ethyl benzene (EB) on humoral immune function in female SD rats exposed to 0, 25, 125 and 500 ppm EB for 28-d has been assessed using a splenic antibody cell plaque-forming assay (AFC) following sensitisation of the animals to sheep red blood cells. The study was OPPTS 870.7800 compliant, with the results providing a measure of the effect of ethyl benzene on humoral immune responses. The results showed that spleen and thymus weights from exposed animals were unremarkable, with no treatment-related effects on spleen cell number or IgM AFC responses in red blood cell-sensitised animals. In contrast spleen and thymus weights, together with specific and total IgM AFC, were clearly and significantly reduced after cyclophosphamide treatment (positive control substance). The results demonstrate that sub-acute exposure to up to 500 ppm ethyl benzene vapour for 28 -d was without effect on the humoral component of the rat immune system.

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This information has no impact on classification.