Registration Dossier
Registration Dossier
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EC number: 201-204-4 | CAS number: 79-41-4
Endpoint summary
Administrative data
Description of key information
LC50 fish (96h): 85 mg/l (Oncorhynchus mykiss)
NOEC/LC10 fish (35d): 10 mg/l (Danio rerio)
EC50 Daphnia (48h): > 130 mg/l
NOEC Daphnia (21d): 53 mg/l
EC50 algae (72h): 45 mg/l (growth rate) (Pseudokirchnerella subcapitata)
NOEC algae (72h): 8.2 mg/l (growth rate) (Pseudokirchnerella subcapitata)
EC10 microorganisms (17h): 100 mg/l (Pseudomonas putida)
Additional information
Data availability: For MAA acute as well as chronic studies of sufficient reliability are available for all three trophic levels and also reliable microbial toxicity data.
Summary:
The aquatic toxicity of methacrylic acid was investigated on all three trophic levels using acute as well as long-term toxicity tests. The results of acute aquatic toxicity tests indicated that the test substance is of low toxicity to aquatic invertebrates (EC50 Daphnia magna: > 130 mg/L) and harmful to fish (LC50 fish (96h): 85 mg/l (Oncorhynchus mykiss) and algae [ECr50 (72h): 45 mg/L, NOEC (72h): 8.2 mg/l with Pseudokirchneriella subcapitata].
In the long-term toxicity tests, fish toxicity in an early life stage test with Danio rerio was the most sensitive endpoint with a NOEC of 10 mg/L, while a 21d Daphnia reproduction test had a NOEC of 53 mg/L.
The microbial EC10 (17h) was determined to be 100 mg/L based on growth inhibition of Pseudomonas putida.
As methacrylic acid has no potential to bioaccumulate in organisms and is readily biodegradable in OECD 301 screening tests ( fulfilling 10 day window) the substance does not have to be classified of environmental hazard acc. EU CLP criteria.
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