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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 September 2017 to 10 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
liquid chromatography
other: ICP-MS
Type:
log Pow
Partition coefficient:
-0.9
Temp.:
19.7 °C
pH:
>= 8.3 - <= 8.6
Remarks on result:
other: Partition coefficient of polyborate moiety.
Remarks:
The pH measured for the samples is in the environmental range (5-9) and therefore this was considered to have no impact in the study and the results.
Type:
log Pow
Partition coefficient:
-2.5
Temp.:
19.7 °C
pH:
>= 8.3 - <= 8.6
Remarks on result:
other: Partition coefficient for organic moiety.
Remarks:
The pH measured for the samples is in the environmental range (5-9) and therefore this was considered to have no impact in the study and the results.
Details on results:
The log Pow values were within the acceptable range of ± 0.3 log units.

Partition coefficient for polyborate moiety:

Ratio
n-octanol : water [v:v]

Analyzed concentration

Pow

log Pow

pH

n-octanol
[g/L]

water
[g/L]

individual

mean

1:1

0.441

3.25

1.4 x 10-1

1.4 x 10-1

-0.9

8.5

 

0.441

3.13

1.4 x 10-1

 

-0.9

8.5

1:2

0.381

2.72

1.4 x 10-1

1.4 x 10-1

-0.9

8.3

 

0.381

2.60

1.5 x 10-1

 

-0.8

8.3

2:1

0.541

4.41

1.2 x 10-1

1.3 x 10-1

-0.9

8.6

 

0.531

4.14

1.3 x 10-1

 

-0.9

8.6

Mean

1.4 x 10-1

 

-0.9

 

Standard deviation

8.9 x 10-3

 

 

 

 

Partition coefficient for organic moiety:

Ratio
n-octanol : water [v:v]

Analyzed concentration

Pow

log Pow

pH

n-octanol
[g/L]

water
[g/L]

individual

mean

1:1

0.00905

2.95

3.1 x 10-3

3.1 x 10-3

-2.5

8.5

 

0.00942

2.93

3.2 x 10-3

 

-2.5

8.5

1:2

0.00529

2.26

2.3 x 10-3

2.3 x 10-3

-2.6

8.3

 

0.00493

2.18

2.3 x 10-3

 

-2.6

8.3

2:1

0.0189

4.26

4.4 x 10-3

4.4 x 10-3

-2.4

8.6

 

0.0185

4.30

4.3 x 10-3

 

-2.4

8.6

Mean

3.3 x 10-3

 

-2.5

 

Standard deviation

9.3 x 10-4

 

 

 

 

Conclusions:
The partition coefficient (log Pow) of Reaction products of monoethanolamine and boric acid (1:3) in an OECD 107 study conducted under GLP conditions was the following:
- at 19.7°C, pH 7, for the polyborate moiety: -0.9.
- at 19.7°C, pH 7, for the organic moiety: -2.5.
The determined log Pow values were within the acceptable range of ± 0.3 log units.
Executive summary:

The n-octanol/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8. The analytical methods were validated following SANCO/3029/99 rev. 4. The determined partition coefficient (log Pow) at 19.7°C, pH 8.3 -8.6, for the polyborate moiety is -0.9. The determined partition coefficient (log Pow) at 19.7°C, pH 8.3-8.6, for the organic moiety is -2.5.

Description of key information

The partition coefficient (log Pow) of Reaction products of monoethanolamine and boric acid (1:3) in an OECD 107 study conducted under GLP conditions was the following:

- at 19.7°C, pH 7, for the polyborate moiety: -0.9.

- at 19.7°C, pH 7, for the organic moiety: -2.5.

Key value for chemical safety assessment

Additional information