Registration Dossier
Registration Dossier
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EC number: 202-510-0 | CAS number: 96-49-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets scientific standards
Data source
Reference
- Reference Type:
- publication
- Title:
- Enzymatic Hydrolysis of Organic Cyclic Carbonates
- Author:
- Yang YL, Ramaswamy SG, Jakoby WB
- Year:
- 1 998
- Bibliographic source:
- J Biol Chem 273: 7814-7817
Materials and methods
- Principles of method if other than guideline:
- Rat liver enzyme active in hydrolysis studied in vitro
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylene carbonate
- EC Number:
- 202-510-0
- EC Name:
- Ethylene carbonate
- Cas Number:
- 96-49-1
- Molecular formula:
- C3H4O3
- IUPAC Name:
- 1,3-dioxolan-2-one
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals
Constituent 1
Results and discussion
Any other information on results incl. tables
The enzyme appeared to be identical to rat liver imidase. The activity is dependent on pH (higher activity at pH > 7).
Applicant's summary and conclusion
- Conclusions:
- Hydrolysis by rat liver imidase
- Executive summary:
The rat liver enzyme imidase catalyses the hydrolysis of ethylene carbonate; higher activity was measured at pH>7.
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