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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
2.66 µg/L

Additional information

In a 21d Daphnia reproduction study according to OECD 211 and GLP using 14C test material, a NOEC of 2.66 µg/L (mean measured) was derived (BASF SE, DSM Nutritional Products AG, Merck KGaA, Symrise AG, 2018). In this study 5 concentrations have been tested, a clear concentration response on daphnid reproduction was observed.

In contrast, in a scientific publication a NOEC of > 50 µg/L was derived from a 21 d Daphnia reproduction test (non-GLP, no analytics), however some information on the test design and detailed study results are missing. Therefore, the results from the recent GLP study of higher quality should be taken for the hazard assessment of the substance.