Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 208-764-9 | CAS number: 541-02-6
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
There are two reliable studies that have investigated the effects of D5 on the liver and induction of liver enzymes (Dow Corning Corporation, 1989; WIL Research Laboratories, Inc, 1997). There are also two reliable studies into the effects of D5 on the release of prolactin (Dow Corning Corporation, 2010a, b).
Additional information
There are two reliable studies that showed that D5 induce the drug metabolizing enzymes in the liver microsomes in a manner similar to that of phenobarbital (Dow Corning Corporation, 1989; WIL Research Laboratories, Inc, 1997).
There are two reliable studies that investigated the potential effects of D5 on serum prolactin concentrations (Dow Corning Corporation, 2010a, b). These studies showed that inhaled D5 did not decrease prolactin concentrations in Fischer 344 rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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