Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted calculation method
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR Database
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July 2008
Principles of method if other than guideline:
Dermwin v2.01 (Q)SAR database report

Test material

Constituent 1
Chemical structure
Reference substance name:
Sorbitan laurate
EC Number:
215-663-3
EC Name:
Sorbitan laurate
Cas Number:
1338-39-2
Molecular formula:
C18H34O6
IUPAC Name:
1,4-anhydro-6-O-dodecanoyl-D-glucitol

Results and discussion

Absorption in different matrices:
Dermal absorption of the test substance was predicted to be very low with an estimated dermal permeability coefficient (Kp) of 0.00222 cm/h and a dermal absorption rate of 0.00076 mg/cm²/h (=0.000189 mg/cm²/event).

Applicant's summary and conclusion