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Toxicological information

Endpoint summary

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Administrative data

Link to relevant study record(s)

Description of key information

CaNa2EDTA does not penetrate the skin.

Key value for chemical safety assessment

Additional information

In a study on male, young, and healthy male volunteers, Foreman & Trujillo (1954) investigated the dermal absorption of CaNa2EDTA. 3 mg of a mixture of 14C labeled and unlabeled substance were prepared in water soluble base (resulting paste was applied over an area of 100 cm² for 24 h under occlusive conditions). In one study, NaEDTA salt was used instead of CaEDTA salt. The maximum activity in the urine was 0.001% of the administered dose. For for justification for read-across see chapter 13 of this dossier.