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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
repeated dose toxicity: oral
Remarks:
combined repeated dose and reproduction / developmental screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: DE4550000
Year:
2012
Bibliographic source:
RTECS(Registry of Toxic Effects of Chemical Substances);JTSCDR Journal of Tox. Sci.(Japanese Soc. of Toxicological Sciences,4th Floor,Gakkai Center Bldg.,4-16,Yayoi 2-chome,Bunkyo-ku,Tokyo 113, Japan)V.1-1976-Vol.(issue)/page/year: 6,246,1981
Reference Type:
publication
Title:
Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan
Author:
JTSCDR Journal of Toxicological Sciences.
Year:
1981
Bibliographic source:
V.1- 1976- Volume(issue)/page/year: 6,246,1981

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
combined repeated dose and reproduction / developmental screening
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Substance type: organic
- Physical state:solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration of treatment / exposure:
36 Weeks (continuous)

Results and discussion

Effect levels

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
756 000 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain.

Applicant's summary and conclusion

Executive summary:

Kidney/Ureter/Bladder - other changes in urine composition Kidney/Ureter/Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain was observed in the multiple dose toxicity study for this substance.