Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-886-1 | CAS number: 128-44-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: QSAR prediction
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for "Primary Irritation Index" read across evaluation for 128-44-9
- Author:
- Sustainability SUpport Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- http://www.oecd.org/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- EC Number:
- 204-886-1
- EC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Cas Number:
- 128-44-9
- Molecular formula:
- C7H5NO3S.Na
- IUPAC Name:
- sodium 1,1,3-trioxo-2,3-dihydro-1H-1λ⁶,2-benzothiazol-2-ide
- Details on test material:
- SMILES:C1(=O)c2c(cccc2)S(=O)(=O)N{-}1.[Na]{+}
Constituent 1
Test animals
- Species:
- other: human;rabbit
Test system
- Type of coverage:
- occlusive
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Primary irritation index
- Basis:
- animal: human; rabbit
- Time point:
- other: not available
- Score:
- 1.7
- Remarks on result:
- other: not irritating
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 5 nearest neighbours
(("a"
and "b" )
and ("c"
and "d" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
C1(=O)c2c(cccc2)S(=O)(=O)N{-}1.[Na]{+}
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Similarity
boundary:Target:
C1(=O)c2c(cccc2)S(=O)(=O)N{-}1.[Na]{+}
Threshold=80%,
Dice(Atom pairs)
Domain
logical expression index: "c"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -1.86
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -1.53
Applicant's summary and conclusion
- Interpretation of results:
- other: 1.7
- Executive summary:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
