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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
119.839 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: Neutral Organic SAR (Baseline Toxicity)
Validity criteria fulfilled:
not specified
Conclusions:
Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on daphnia magna was predicted for test substance. The estimated NOEC values for aquatic invertebrate after 21 days was 119.839 mg/l on the basis of mobility.
Executive summary:

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on daphnia magna was predicted for test substance. On the basis of effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 119.839 mg/l for daphnia magna for 21 day duration. On the basis of this value, it can be concluded that the test chemical can be considered as non-toxic to daphnia magna and can be considered to be not classified as per the CLP classification criteria.

Description of key information

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on daphnia magna was predicted for test substance. On the basis of effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 119.839 mg/l for daphnia magna for 21 day duration. On the basis of this value, it can be concluded that the test chemical can be considered as non-toxic to daphnia magna and can be considered to be not classified as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
119.839 mg/L

Additional information

Summarized result for the toxicity of test chemical on the growth and mobility of daphnia magna were determine and mention as below:

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on daphnia magna was predicted for test substance. On the basis of effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 119.839 mg/l for daphnia magna for 21 day duration. On the basis of this value, it can be concluded that the test chemical can be considered as non-toxic to daphnia magna and can be considered to be not classified as per the CLP classification criteria.

Similar study was conducted to determine the long term toxicity of test chemical on the mortality rate of daphnia magna. Test conducted in the open system under the semi-static method. 4 replicates were used in which 10 organisms were used in each replicates. Control of DMSO: HCO-40 was 9:1 (100 mg/kg). Test conducted on the nominal concentration for 7 days, 14 days and 21days. After the exposure of chemical lethal concentration was measured. Based on the mortality rate of daphnia magna due to the long period exposure with chemical, the LC50 value was observed at 13 mg/l, 10 mg/l and 9.7 mg/l for 7 days, 14 days and 21 days of exposure. The EC50 was 4.4 and 9.1 after 14 and 21 days of exposure. Based on the LC50, it can be concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

Thus based on the above data and results, chemical consider to be nontoxic to the aquatic invertebrates and not classified as per the CLP classification criteria.