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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Prediction done using ECOSAR v.1.11 model
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
28 d
Test temperature:
25 Deg.C
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
307.146 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral Organic SAR (Baseline Toxicity)
Validity criteria fulfilled:
not specified
Conclusions:
Based on the EPI Suite ECOSAR prediction model, the 28 d NOEC value was estimated to be 307.146 mg/l on Fish for test substance on the basis of mortality effects.
Executive summary:

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 307.146 mg/l for fish for 28 d duration. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to fish and can be considered to be not classified as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 307.146 mg/l for fish for 28 d duration. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to fish and can be considered to be not classified as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
307.146 mg/L

Additional information

Using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 307.146 mg/l for fish for 28 d duration. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to fish and can be considered to be not classified as per the CLP classification criteria.