Registration Dossier
Registration Dossier
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EC number: 204-528-4 | CAS number: 122-20-3
Endpoint summary
Administrative data
Description of key information
With high probability, the substance is acutely not harmful to aquatic organisms.
Long-term effects are not expected.
Additional information
Acute toxicity to fish
The results as presented by a BASF AG study from 1987 indicate that the test substance is not harmful to fish. The 96 -h LC50 value calculated as geometrical mean is 3158 mg/L. Results are supported by an acute toxicty test according to EU Method C.1 (Acute Toxicity for Fish) from Hüls (1997). In the limit-test no mortality was observed at 1000 mg/L (LC50 (96 h) >1000 mg/L, nominal confirmed by concentration control analytics).
Long-term toxicity to fish
In a fish-early-life stage study according to OECD 210, the 35-d NOEC was determined to be >= 10 mg/L (nom., analytically verified; Isopropanol Amines Consortium, 2022).
Acute toxicity to invertebrates
The results as presented in a BASF AG study conducted in 1987 indicate that the test substance is with high probability not acutely harmful to aquatic invertebrates. The EC50 based on mobility was determined to be > 500 mg/L.
The results are supported by an acute toxicty test according to EU Method C.2 (Acute Toxicty for Daphnia) from Hüls (1997). The EC50 (48 h) was measured to be 857 mg/L (nominal, analytically verified).
Long-term toxicity to aquatic invertebrates
In a Daphnia magna reproduction study according to OECD 211, the 21-d NOEC was determined to be >= 10 mg/L (nom., analytically verified; Isopropanol Amines Consortium, 2022).
Toxicity to aquatic algae
In order to determine the effects of 2-Propanol, 1,1',1''-nitrilotris- (CAS 122-20-3) on aquatic algae, there are experimental data from a study sponsored by Sasol Germany GmbH (1997; formerly Huels GmbH) available. In a test according to EU method C.3 with Desmodesmus subspicatus the 72-h ErC50 was determined to be 710 mg/L, the 72-h ErC10 was found to be 9.4 mg/L. In a supporting study by BASF (1990) the ErC50, recalculated from the fluorescence data, after 72 hours of exposure was determined to be > 100 mg/L.
Toxicity to microorganisms
There is one valid study according to ISO 8192 available (BASF AG, 1981). The study resulted in an EC20 value of > 1995 mg/L. However the test was performed using industrial activated sludge. According to the "Guidance on information requirements and chemical safety assessment, chapter R.7b: Endpoint specific guidance, point R.7.8.17.1" industrial activated sludge is considered to be adapted to the test substance and the results can not be extrapolated to domestic activated sludge. Hence the results can not be used for a hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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