Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-746-9 | CAS number: 71-23-8
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Human patch test
Patch tests were exposed for 48 hours using Finn Chambers (inner diameter 8 mm) on Scanpor tape (Smart-Practice, Greven, Germany). Reading of results was performed on day (D) 2 and D3 according to the current guidelines of the German Contact Dermatitis Research Group. Patients with positive results underwent an additional D7 reading. As a standard operating procedure in the clinic for patch tests, patients were reminded to revisit the clinic in case of any novel reaction on D7. In case of uncertainty, patients were asked to send in a photo in advance, if they refrained from taking the trip to our hospital. However, no such revisit was necessary on or around D7 in the study cohort.
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
Constituent 1
- Specific details on test material used for the study:
- 1-propanol 10% aq.
Method
- Type of population:
- general
- occupational
- Subjects:
- 145
- Route of administration:
- dermal
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Among 145 patients patch tested with i.a. propan-1-ol, only one nurse was detected with a possible allergy to 1-propanol. The clinical relevance of the positive patch test result was controlled by repetitive open application tests (ROATs), which were performed two times daily over 7 days. Although the first ROAT was positive, a second one was not able to confirm the finding.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
