Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6,10,15,19,23-hexamethyltetracosane
EC Number:
203-825-6
EC Name:
2,6,10,15,19,23-hexamethyltetracosane
Cas Number:
111-01-3
Molecular formula:
C30H62
IUPAC Name:
2,6,10,15,19,23-hexamethyltetracosane

Results and discussion

Any other information on results incl. tables

The endpoints examined by this predictive software are listed below :

Super endpoints :  Carcinogenicity  Chromosome damage  Genotoxicity  HERG channel inhibition  Hepatotoxicity  Irritation  Miscellaneous endpoints  Mutagenicity  Ocular toxicity  Rapid prototypes: bladder disorders  Rapid prototypes: blood in urine  Rapid prototypes: bone marrow toxicity  Rapid prototypes: bradycardia  Rapid prototypes: chromosome damage in vitro  Rapid prototypes: hepatotoxicity  Rapid prototypes: kidney disorders  Rapid prototypes: mitochondrial disfunction  Rapid prototypes: nephrotoxicity  Rapid prototypes: splenotoxicity  Rapid prototypes: testicular toxicity  Rapid prototypes: thyroid toxicity  Reproductive toxicity  Respiratory sensitization  Skin sensitization  Thyroid toxicity

Miscellaneous endpoints :  alpha-2-mu-Globulin nephropathy  Anaphylaxis  Bladder urothelial hyperplasia  Cardiotoxicity  Cerebral oedema  Chloracne  Cholinesterase inhibition  Chromosome damage in vitro  Cumulative effect on white cell count and immunology  Cyanide-type effects  High acute toxicity  Methaemoglobinaemia  Nephrotoxicity  Neurotoxicity  Oestrogenicity  Peroxisome proliferation  Phospholipidosis  Phototoxicity  Pulmonary toxicity  Uncoupler of oxidative phosphorylation

Of these endpoints, no alerts were triggered by the structure of the substance.

Applicant's summary and conclusion

Conclusions:
Of the 45 endpoints examined, no alerts were triggered by the structure of the substance.
Executive summary:

The DEREK Nexus system has been designed for the qualitative prediction of the possible toxicity of chemicals. Of the 45 endpoints examined, no alerts were triggered by the structure of the substance.