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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information is included as attachment in Section 13.
Reason / purpose for cross-reference:
read-across source
Group:
positive control
Remarks on result:
other: No positive control animal group included
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
50 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No skin reactions were noted
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
25 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No skin reactions were noted
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
50 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No skin reactions were noted
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
25 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No skin reactions were noted
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
50 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
5
Clinical observations:
No other skin reactions were noted
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
25 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
5
Clinical observations:
No other skin reactions were noted
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
50 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
5
Clinical observations:
No other skin reactions were noted
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
25 % w/w of strontium chloride-6-hydrate extra pure
No. with + reactions:
0
Total no. in group:
5
Clinical observations:
No other skin reactions were noted
Interpretation of results:
GHS criteria not met
Conclusions:
Based on the read-across from Strontium chloride, Strontium carbonate is not expected to be a skin sensitizer.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

Sensitisation:

The reference Allen (1997) is considered as the key study on skin sensitisation and will be used for classification. The overall sensitisation results are as follows:

The test material, Strontium chloride-6-hydrate extra pure, produced a 0 % (0/10) sensitisation rate and was classified as a non-sensitiser to guinea pig skin. According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is not classified as skin sensitizer. According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as Category 1.

 

Respiratory sensitisation:

During long-year industrial practice no cases of hypersensitivity were observed till now by workers exposed exclusively to strontium carbonate. Thus, no classification as respiratory sensitiser according to regulation (EC) 1272/2008 is required.