Registration Dossier
Registration Dossier
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EC number: 201-234-8 | CAS number: 79-92-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro:
In vitro gene mutation in bacteria: Weight of evidence: Experimental results from independent sources and read-across. Camphene was not mutagenic in all strains/cell types with and without metabolic activation.
In vitro cytogenicity study in mammalian cells: Key study: read-across from analogues. Read-across analysis shows that Camphene is negative against chromosomal aberrations with and without S9.
In vitro mammalian gene mutation study: Key study: Camphene, technical grade, solid did not induce gene mutations in presence and absence of metabolic activation in cultured mammalian cells (L5178Y/TK+/- 3.7.2 C mouse lymphoma cell line) used.
In vitro gene mutation study in mammalian cells: Supporting study: read-across from analogue. Read-across analysis shows that Camphene is negative for the in vitro gene mutation assay in mammalian cells, with and without S9.
Genetic toxicity in vivo: Key study: Camphene was not mutagenic in the micronucleus test (mice).Test method was according to OECD guideline 474.
Short description of key information:
Genetic toxicity in vitro:
In vitro gene mutation in bacteria: Weight of evidence: Experimental results from independent sources and read-across. Camphene was not mutagenic in all strains/cell types with and without metabolic activation.
In vitro cytogenicity study in mammalian cells: Key study: read-across from analogues. Read-across analysis shows that Camphene is negative against chromosomal aberrations with and without S9.
In vitro mammalian gene mutation study: Key study: Camphene, technical grade, solid did not induce gene mutations in presence and absence of metabolic activation in the cultured mammalian cells (L5178Y/TK+/- 3.7.2 C mouse lymphoma cell line) used.
In vitro gene mutation study in mammalian cells: Supporting study: read-across from analogue. Read-across analysis shows that Camphene is negative for the in vitro gene mutation assay in mammalian cells, with and without S9.
Genetic toxicity in vivo: Key study: Camphene was not mutagenic in the micronucleus test (mice). Test method was according to OECD guideline 474.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results obtained in the in vitro and in vivo studies, the substance is not classified.
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