Registration Dossier
Registration Dossier
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EC number: 201-234-8 | CAS number: 79-92-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Basic toxicokinetics: Supporting studies: After 30 minutes, 90% of injected camphene was detected in the respiratory air (human).
Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.
Short description of key information on absorption rate:
Dermal absorption: Supporting studies: Camphene is readily absorbed following a topical application.
After a 30-min full bath with pine oil, one human subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
Key value for chemical safety assessment
Additional information
Basic toxicokinetics:
Supporting studies: Experimental results: After 30 min, 90% of injected camphene was detected in the respiratory air (human).
Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.
Dermal absorption:
Supporting studies: Experimental results: Camphene is readily absorbed following a topical application.
After a 30-min full bath with pine oil, one human subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
Discussion on bioaccumulation potential result:
Supporting studies: Experimental results: After 30 minutes, 90% of injected camphene was detected in the respiratory air (human). Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine. Test method was not according to any guideline.
Discussion on absorption rate:
Supporting studies: Experimental results:
Camphene is readily absorbed following a topical application.
After a 30-min full bath with pine oil, one human subject exhaled terpenes, including 0.67 µL camphene, within 5 hr. A constant of 81 µL/cm2/hr was calculated for the percutaneous absorption of camphene from the bath.
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