Registration Dossier
Registration Dossier
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EC number: 244-073-9 | CAS number: 20837-86-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study was preformed according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Lead cyanamidate
- EC Number:
- 244-073-9
- EC Name:
- Lead cyanamidate
- Cas Number:
- 20837-86-9
- Molecular formula:
- CN2.Pb
- IUPAC Name:
- λ²-lead(2+) (azanidylenemethylidene)azanide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Doses:
- four levels: 5, 50, 300 and 2000 mg/kg body weight
- No. of animals per sex per dose:
- 3 animals of a single sex per step.
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Mortality:
- It was noted the death of two rats treated at 2000 mg/kg body weight at 22 hours 55 minutes and at 27 hours 35 minutes post-dose, respectively. The macroscopical examination of the dead animals revealed a thinning of the forestomach (2/2) associated with a white coloration (1/2), a thinning of the corpus associated with a dark red to black coloration (1/2), and presence of a red liquid in the thorax (2/2).
- Clinical signs:
- other: In the survival animals, it was noted from 24 hours post-dose, a dyspnoea (4/4), tremors (4/4), piloerection (4/4) and a decrese in spontaneous activity (2/4). The animals recovered a normal behaviour on 4 days.
- Gross pathology:
- The macroscopical examination of the animal at the end of the study did not reveal treatment related change.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The presented data are reliable and adequate.
- Executive summary:
According to the criteria for classification, packaging and labelling of dangerous substance and preparations in accordance with E.E.C. Directives 67/548, 2001/59 and 99/45, the test item must not be classified. In accordance with the regulation EC No 1272/2008, the test item need not be classified. No signal word or hazard statement is required.
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