Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1936
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1936
Report Date:
1936

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Evaluation of a toxikokinetic study:
Hug, E.: Absorption and disappearance of sodium formaldehyde sulfoxylate from the blood after administration intravenously or by stomach tube,
CRSBAW: Comptes rendus des séances de la Societe de Biologie et de ses filiales (ISSN: 0037-9026), (1936), Vol 121, pp 579 -81
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
not applicable
Radiolabelling:
no

Test animals

Species:
dog
Strain:
not specified
Sex:
male

Administration / exposure

Control animals:
no

Results and discussion

Applicant's summary and conclusion

Conclusions:
no effects founds
Executive summary:

Absorption after dermal exposure:

The substance is an organic salt which is highly soluble in water.Additionally, the human epidermis is an excellent barrier for salts, in particular highly water soluble and charged molecules cannot (easily) penetrate such barrier.

Therefore a relevant dermal absorption is not expected.