Registration Dossier
Registration Dossier
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EC number: 205-592-6 | CAS number: 143-22-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report; short study description
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-[2-(2-butoxyethoxy)ethoxy]ethanol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- Exposure times: 1 min, 5 min, 15 min and 20 h
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 0
- Max. score:
- 8
- Irritant / corrosive response data:
- After 1 min, 5 min and 15 min: no irritation.
After 20 hours (back skin): questionable redness.
After 20 hours (ear): light redness.
Skin irritation after 8 days: none.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In an old skin irritation study that pre-dates guidelines, rabbit skin was exposed to 2-(2-(2-butoxyethoxy)ethoxy)ethanol for a period of 20 hours . Both dorsal skin and ear tissue was exposed. The dorsal skin showed slight redness but full recovery was observed within 8 days. Whilst the study did not provide the normal level of detail required for comparison with the classification criteria, the level of response seen was sufficiently slight to be able to conclude with certainty that skin irritancy is not an important characteristic of this substance and that is does not meet the criteria for classification as a skin irritant either under the EU or GHS systems.
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