Ethyl (S)-2-hydroxypropionate

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-01-17 to 2014-04-29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Principles of method if other than guideline:

The vapour pressure of the test substance (PT) was determined by the isothermal thermogravimetric effusion method. The method is validated in the range 10E-08 to 1.0E+03 Pa using a set of five reference substances with known vapour pressures.

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Specific details on test material used for the study:

- Identification: Ethyl-(S)-2-hydroxypropionate
- Molecular formula: C5H10O3
- Batch: 1007002470
- Purity/composition: 98 %
- Test substance storage: At room temperature in the dark under nitrogen
- Stable under storage conditions until:2015-01-01 (expiry date)

Temp.:

ca. 25 °C

Vapour pressure:

ca. 870 Pa

Temp.:

ca. 25 °C

Vapour pressure:

ca. 6.5 mm Hg

Temp.:

ca. 20 °C

Vapour pressure:

ca. 3.9 mm Hg

Key result

Temp.:

ca. 20 °C

Vapour pressure:

ca. 510 Pa

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of ethyl (S)-lactate. The vapour pressure of the test substance at 20 °C (293 K) was 510 Pa or 3.9 mm Hg, and at 25 °C (298 K) it was 870 Pa or 6.5 mm Hg, respectively.

Executive summary:

The vapour pressure of the test substance ethyl (S)-lactate was determined by the isothermal thermogravimetric effusion method (TGA). The test item was placed in an oven and consequently stepwise isothermal heated. The weight-loss of the test item was measured and the vapour pressure determined by comparison with reference substances. Each reference substance and the test item were measured in duplicate by TGA.

Reference 2

Endpoint:

vapour pressure

Type of information:

other: publication

Adequacy of study:

supporting study

Study period:

1998

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

Standard overview of vapour pressure values for lactate esters, based on company in-house data.

GLP compliance:

no

Temp.:

20 °C

Vapour pressure:

2.2 hPa

Conclusions:

The vapour pressure of ethyl (S)-lactate is 2.2 hPa at 20 °C.

Executive summary:

According to Clary, the vapour pressure of ethyl (S)-lactate has been determined to 2.2 hPa at 20 °C.

Description of key information

The isothermal TGA effusion method was applied for the determination of the vapour pressure of ethyl (S)-lactate. The vapour pressure of the test substance at 20 °C (293 K) was 510 Pa or 3.9 mm Hg, and at 25 °C (298 K) it was 870 Pa or 6.5 mm Hg, respectively.

Key value for chemical safety assessment

Vapour pressure:

510 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test substance ethyl (S)-lactate was determined by the isothermal thermogravimetric effusion method (TGA). The test item was placed in an oven and consequently stepwise isothermally heated. The weight-loss of the test item was measured and the vapour pressure determined by comparison with reference substances. Each reference substance and the test item were measured in duplicate by TGA.