Registration Dossier
Registration Dossier
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EC number: 213-424-8 | CAS number: 947-04-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- see Test Conditions
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dodecane-12-lactam
- EC Number:
- 213-424-8
- EC Name:
- Dodecane-12-lactam
- Cas Number:
- 947-04-6
- Molecular formula:
- C12H23NO
- IUPAC Name:
- 1-azacyclotridecan-2-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous tragacanth suspension
- Details on exposure:
- - Doses per time period: single dose
- Volume administered or concentration: 0.5 / 1 / 2.5 / 5 / 6 / 7.5 / 10 %
- Post dose observation period: 7 days - Doses:
- 50 / 100 / 250 / 500 / 600 / 750 / 1000 mg/kg bw
- No. of animals per sex per dose:
- 10 (total)
- Control animals:
- not specified
- Statistics:
- Litchfield and Wilcoxon
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 410 mg/kg bw
- Mortality:
- - Time of death: within 24 hours
- Number of deaths at each dose:
50 mg/kg: 0
100 mg/kg: 2
250 mg/kg: 2
500 mg/kg: 5
600 mg/kg: 7
750 mg/kg: 9
1000 mg/kg: 10 - Clinical signs:
- (similar to) impairment of breathing, slight muscle tremor, sedative effects, reduced general condition, beginning 1/2 hour after dosing and reversible within 24 hours, observed in all dose levels except lowest
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
