Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: original reference not translated (Russian)
Data source
Reference
- Title:
- No information
- Author:
- Burlaka-Vovk, Z.I. et al.: in Endocrine system and toxic|environmental factors. Leningrad; 1979: 19-24: cited in|Chlorobenzenes (Series "Scientific Reviews of Soviet Lit-|erature of Toxicity and Hazards of Chemicals"), edited by |Izmerov, N.F., Centre for International Projects, GKNT, |Moscow, 1988; data compiled by Vasilenko, N.M. and Semilet-|kina, N.N. (number of issue: 108)
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 7-8 months
- Frequency of treatment:
- 4 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05 mg/l
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Effects on adrenal cortex function: short increase in the blood plasma level of 11-oxycorticosteroids at 3 and 5 months of exposure.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
