Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-619-1 | CAS number: 25103-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Oral route
The potential acute toxicity of tert-dodecanethiol, following a single oral administration (gavage) to rats was evaluated in a study conducted in compliance with OECD Guideline No. 423 (Tarcai, 2017). Tert-dodecanethiol in corn oil was administered once by oral route (gavage) at the dose level of 2000 mg/kg bw to two groups of three fasted female Wistar rats under a dosage-volume of 10 mL/kg. After the first assay with 3 females, as no mortality was observed, the results were confirmed in other 3 females. Each animal was observed at least once a day for mortality and clinical signs for 15 days. Body weight was recorded on days 0 (prior to administration), 7 and 14. On completion of the observation period, the animals were sacrificed and then submitted for a macroscopic post-mortem examination. No unscheduled deaths occurred during the study. Hunched back up to Day 2, incoordination (score 1) up to Day 1 in 6/6 animals and red discharge around the nose in 3/6 animals on Day 1 were observed. The animals were symptom-free from Day 3. When compared to historical control data, no change in body weight gain was noted. No macroscopic finding was observed. The oral LD0 of tert-dodecanethiol was higher than 2000 mg/kg in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 17th Dec. 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Research Models and Services, Germany GmbH, Sandhofer Weg 7, D-97633 Sulzfeld
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 8 - 12 weeks old
- Weight at study initiation: 150-300 g
- Fasting period before study: yes
- Housing: group caging (3 animals/cage)
- Diet (e.g. ad libitum): ssniff® SM R/M "Autoclavable complete diet for rats and mice–breeding and maintenance"
- Water (e.g. ad libitum): tap water from the municipal supply
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 - 70
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals will be observed individually after dosing at least once during the first 30 minutes, then 1, 2, 3, 4 and 6 hours after the treatment and once each day for 14 consecutive days thereafter. The body weights will be recorded on Days -1 (prior to removal of food), 0 (prior to administration), 7 and 14.
- Necropsy of survivors performed: yes - Statistics:
- None
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- Hunched back up to Day 2, incoordination (score 1) up to Day 1 in 6/6 animals and red discharge around the nose in 3/6 animals on Day 1 were observed. The animals were symptom-free from Day 3.
- Body weight:
- No effect.
- Gross pathology:
- No effect.
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The potential acute toxicity of tert-dodecane thiol, following a single oral administration (gavage) to rats was evaluated in a study conducted in compliance with OECD Guideline No. 423. Tert-dodecane thiol in corn oil was administered once by oral route (gavage) at the dose level of 2000 mg/kg bw to two groups of three fasted female Wistar rats under a dosage-volume of 10 mL/kg. After the first assay with 3 females, as no mortality was observed, the results were confirmed in other 3 females. Each animal was observed at least once a day for mortality and clinical signs for 15 days. Body weight was recorded on days 0 (prior to administration), 7 and 14. On completion of the observation period, the animals were sacrificed and then submitted for a macroscopic post-mortem examination. No unscheduled deaths occurred during the study. Hunched back up to Day 2, incoordination (score 1) up to Day 1 in 6/6 animals and red discharge around the nose in 3/6 animals on Day 1 were observed. The animals were symptom-free from Day 3. When compared to historical control data, no change in body weight gain was noted. No macroscopic finding was observed. The oral LD0 of tert-dodecane thiol was higher than 2000 mg/kg in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the available data and CLP criteria, no classification is warranted for the acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1