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Key value for chemical safety assessment

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Endpoint specific guidance (ECHA, 2008) indicates that absorption of substances following exposure by inhalation, skin contact or ingestion may be predicted based on log Pow and water solubility. Experimentally determined results for Terpenes and terpenoids, turpentine-oil, alpha pinene fraction, oligomers are:

 

* Partition coefficient n-octanol/water (log value): >4.04

* Water solubility: <0.322 mg/L.

 

ECHA (2008) indicates that uptake of substances by the lung and by the gastrointestinal tract is favoured by moderate log P values (between -1 and 4) with micellular solubilisation favoured where log P is >4 and water solubility is low (< 1 mg/l). Data summarised above indicate that the log Pow for this substance exceeds 4 and water solubility is low suggesting that some uptake after exposure via these routes may occur although the extent of uptake is unclear.

 

For dermal absorption to occur, a substance must be sufficiently soluble in water to partition from the stratum corneum into the epidermis with low uptake if the water solubility is below 1 mg/l (ECHA 2008). Log P values between 1 and 4 favour dermal absorption, while a log P >4 limits the rate of transfer between the stratum corneum and the epidermis limiting skin penetration. Phys-chem data summarised above suggests that Terpenes and terpenoids, turpentine-oil, alpha pinene fraction, oligomers should not be readily absorbed by skin.

 

No experimental data are available to characterise the toxicokinetic behaviour of this substance.