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EC number: 251-118-6 | CAS number: 32588-76-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
EBTBP was administered as a single dose of 2,000 mg/kg to the clipped skin of 6 albino rabbits. The skin of three of the animals was abraded prior to treatment. The test site was wrapped with an impervious material. The wrapping was removed at 24 hr, any excess test article removed, and the animals observed for 14 days. No animals died during the test. The dermal LD50 was > 2,000 mg/
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines. The study was performed prior to established guidelines and GLPs.
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.41 - Hazardous Substances and Articles, Administration and Envforcement Regulations, U.S. Federal Register, 38(187), p 27019, 27 Sept 1973.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Principles of method if other than guideline:
- 5 male and 5 female rats administered a single oral dose by gavage in corn oil of 7.5 g/kg, and observed for 14 d.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Single oral dose of 7.5 g/kg bw
- No. of animals per sex per dose:
- 5 males and 5 female
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 7.5 other: gm/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no rats died on test
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- EBTBP was not acutely toxic to rats by the oral route.
- Executive summary:
One group of 5 male and 5 female Sherman-Wistar rats was administered a single dose of EBTBP by gavage in corn oil at 7,500 mg/kg. The animals were observed for 14 days. No animals died on test. The oral LD50 was > 7,500 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 7 500 mg/kg bw
- Quality of whole database:
- No lethality or adverse effects were observed after acute oral, dermal and inhalation exposure of the substance at or above the limit doses.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- aerodynamic dyameter of particle size = 6.0 microns +- 2.22.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric
- Duration of exposure:
- 1 h
- Concentrations:
- 203 mg/L
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 203 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The 1 hr LC50 was > 203 mg/L.
- Executive summary:
One group of 5 male and 5 female albino rats was exposed to EBTBP at a concentration of 203 mg/L for 1 hour. Dyspnea and nasal discharge were the principal signs observed during the exposure. No deaths occurred during treatment or the during the 14 day observation period. The inhalation LC50 was > 203 mg/L for 1 hour. This study was performed according to Good Laboratory Practices.
Reference
No rats died on the study.
Dyspnea was observed during the exposure and continued post-exposure (up to 5 days) in a few animals. Mean body weight gain was normal 14 days after exposure. At necropsy, red foci in the lungs of a few rats were observed.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 203 000 mg/m³ air
- Quality of whole database:
- One group of 5 male and 5 female albino rats was exposed to EBTBP at a concentration of 203 mg/L for 1 hour. Dyspnea and nasal discharge were the principal signs observed during the exposure. No deaths occurred during treatment or the during the 14 day observation period. The inhalation LC50 was > 203 mg/L for 1 hour. This study was performed according to Good Laboratory Practices.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines. The study was performed prior to established guidelines and GLPs.
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.41 - Hazardous Substances and Articles, Administration and Envforcement Regulations, U.S. Federal Register, 38(187), p 27019, 27 Sept 1973.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Principles of method if other than guideline:
- Test material applied to clipped back of rabbits, covered in place for 24 hr and observed for toxicity and mortality for 14 d.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- other: albino rabbits
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hr
- Doses:
- single dose of 2.0 gm/kg bw
- No. of animals per sex per dose:
- 6 rabbits total
- Control animals:
- no
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 2 other: gm/kg
- Based on:
- test mat.
- Mortality:
- no rabbits died on test
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- EBTBP was not acutely toxic when administered dermally to rabbits.
- Executive summary:
EBTBP was administered as a single dose of 2,000 mg/kg to the clipped skin of 6 albino rabbits. The skin of three of the animals was abraded prior to treatment. The test site was wrapped with an impervious material. The wrapping was removed at 24 hr, any excess test article removed, and the animals observed for 14 days. No animals died during the test. The dermal LD50 was > 2,000 mg/
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines. The study was performed prior to established guidelines and GLPs.
Additional information
The substance did not produce any lethality or toxic effects after acute administraion via the oral, dermal or inhalation route at dose levels up to or above the limit dose.
Justification for selection of acute toxicity – oral endpoint
A valid oral toxicity study in rats is available.
Justification for selection of acute toxicity – inhalation endpoint
A valid acute inhalation study in rats is available.
Justification for selection of acute toxicity – dermal endpoint
A valid dermal toxiicty study in rabbits is available
Justification for classification or non-classification
The substance was not acutely toxic following oral, dermal or inhalation exposure. Therefore a classificaiton for acute toxicity is not warranted.
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