Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Investigation of testicular atrophy
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study is rated a "1" because it applied GLP, and used appropriate testing procedures.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Reference Type:
publication
Title:
Dose-response relationships for induction of hepatic peroxisome proliferation and testicular atrophy by phthalate esters in the rat
Author:
Lake B, Cook W, Worrell N, Cunninghame M, Evans J, Price R, Young P and Carpanini F
Year:
1991
Bibliographic source:
Human and Experimental Toxicology 10:67-68

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
Exposure period: 28 days
Frequency of treatment:
daily

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion