Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study is rated a "4" because the study predates GLP and limited details are provided.

Data source

Reference
Reference Type:
publication
Title:
A Toxicological Investigation of some Acute, Short-Term, and Chronic Effects of Administering Di-2-ethylhexyl Phthalate (DEHP) and Other Phthalate Esters
Author:
Lawrence WH, et al
Year:
1975
Bibliographic source:
Environ Res 9:1-11

Materials and methods

Principles of method if other than guideline:
other : not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: DIDP with different CAS#

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 100 other: g/kg

Applicant's summary and conclusion

Conclusions:
The test substance has a low order of acute toxicity by the i.p route of exposure. The LD50 > 100 g/kg.