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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study is rated a "4" because the study predates GLP and limited details are provided.

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth HF, Jr, et al
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J 23:95-107

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth H.F. et al. Am. Ind. Hyg. Assoc. J. 23:95-107
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: unspecified DIDP isomer

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Age at study initiation: 4-5 wks of age
- Weight at study initiation: 90-120 g
- Diet (e.g. ad libitum): Rockland rat diet, complete

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
14 day observation period following single dose administration
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 60 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
The test substance is assumed to have a low order of acute toxicity by the oral route.
Executive summary:
    
The LD50 of DIDP in rats is greater than 62,080 mg/kg (Smyth et al., 1962).