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Toxicity to aquatic algae and cyanobacteria

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Description of key information

Long-term toxicity to aquatic algae:
Conclusion: Results of a study with an analog substance suggest that DIUP will not produce toxicity to algae at or below its maximum attainable water solubility.

Key value for chemical safety assessment

Additional information

The results of algal toxicity studies are reported EC50and NOEC values. The NOEC values represent the highest concentration measured in these studies that did not demonstrate effects. In all cases this was the highest concentration attainable and measured under the conditions of the study. The use of the NOEC values in the results overview table to derive values for quantitative risk assessment is inappropriate as they are not true NOEC values.

I5 Summary

The toxicity of di-undecyl phthalate ester (DUP) to the green alga (Selenastrum capricornutum) was evaluated in freshwater. No significant effect was observed at the maximum DUP water solubility under the conditions of this study, which measured 2.1 mg/L.The algal dataset includes results for one species,Selenastrum capricornutum (new name:Pseudokirchnerella subcapitata).

The data used to characaterize the algal toxicity of di-isoundecyl phthalate (DIUP) ester are consistent with the data for several high molecular weight phthalate diesters. These data show that high molecular weight phthalate diesters do not produce toxicity to algae at or below their maximum attainable solubliity. These data suggest that DIUP will also not produce algal toxicity.

The data used to characterize DIUP are for diundecyl phthalate (DUP) ester, which is an analog to DIUP. Both DIUP and DUP contain undecyl alkyl groups. Whereas DUP contains linear undecyl alkyl groups, the alkyl groups in DIUP are branched. Therefore, because of the structural similarity between these substances and the similar biological behavior of high molecular weight phthalate esters in general, data for the analog can be used to characterize the biological effects of DIUP for this endpoint.

Staples et al. (1997). Aquatic toxicity of eighteen phthalate esters. Environ. Toxicol. Chem. 16(5): 875 -891.