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Short-term toxicity to fish

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Description of key information

Short-term toxicity to fish:
Results from short term studies with several species of fish on an analog substance demonstrate that DIUP does not cause toxicity at the maximum achievable aqueous concentrations investigated in these tests (i.e. in excess of water solubility).

Key value for chemical safety assessment

Additional information

The results of acute fish toxicity studies are reported as LC50and NOEC values. The NOEC values represent the highest concentration measured in these studies that did not demonstrate mortality. In all cases this was the highest concentration attainable and measured under the conditions of the study. The use of the NOEC values reported in the results overview table to derive values for quantitative risk assessment is inappropriate as they are not true NOEC values.

I5 Summary:

The data used to characaterize the fish acute toxicity of diisoundecyl phthalate (DIUP; CAS #85507 -79 -5) ester are consistent with the data for several high molecular weight phthalate diesters summarized by Staples et al. (1997). These data show that high molecular weight phthalate diesters do not produce acute toxicity to fish at or below their maximum attainable water solublity. The acute fish dataset includes results for various species of freshwater fish including Oncorhynchus mykiss, Pimephales promelas, and Lepomis macrochirus, and a marine fish, Cyprinodon variegatus.

These data suggest that DIUP will also not produce acute toxicity to fish. The data used to characterize DIUP are for diundecyl phthalate (DUP; CAS #3648 -20 -2) ester, which is an analog to DIUP. Both DIUP and DUP contain undecyl alkyl groups. Whereas DUP contains linear undecyl alkyl groups, the alkyl groups in DIUP are branched. Therefore, because of the structural similarity between these substances and the similar biological behavior of high molecular weight phthalate esters in general, data for the analog can be used to characterize the biological effects of DIUP for this endpoint.

Staples et al. (1997). Aquatic toxicity of eighteen phthalate esters. Environ. Toxicol. Chem. 16(5): 875 -891.