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Assessment of the toxicokinetic behaviour of the test substance Tar, brown-coal, low-temp., from available information (literature search and existing study) was performed. No summary toxicokinetic study was found. No experimental data about absorption, distribution or excretion of the test substanceTar, brown-coal, low-temp.,were found in the literature. Due the complex composition of the substance, it is difficult to estimate the behaviour of each individual component. Behaviour of individual components of the test substance in living organisms could be affected by interaction among components. 

In the 9thReport on Carcinogens (NIEHS, 2001), coal tars and coal tar pitches, and untreated and mildly treated mineral oils were listed as known human carcinogens based on sufficient evidence of carcinogenicity in humans. Data available deal mainly with the development of skin cancers. But there were also indications, that when applied to the skin, coal tar induced epidermoid lung carcinomas in rats. One study of millwrights and welders exposed to coal tars and coal tar pitch in a stamping plant showed significant excesses of leukemia and cancers of the lung and digestive organs (IARC S.7, 1987).

These data suggested that during the long-term exposure, the absorption of substances contained in the test substance could occur after dermal exposure