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Short-term toxicity to aquatic invertebrates

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Description of key information

No toxic effects up to the limit of water solubility (< 0.05 mg/L) for Daphnia magna based on read across (OECD 202)

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Additional information

As no valid study is available for assessing the acute toxicity to aquatic invertebrates of 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS No. 94279-36-4), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was conducted. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.

The study with 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was performed under static conditions according to GLP and EU method C.2 using Daphnia magna as test organism (Scholz, 1994). In this limit test the water-accommodated-fraction (WAF) of a 1 g/L stock solution was tested. The mean measured test concentration was 3.2 mg/L with 4.4 mg/L being the highest solubility attained at the beginning of the test (based on DOC content). Hence, under test conditions, the EC50 (48 h) is determined to be > 3.2 mg/L (measured, WAF).

Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as are explained with in the overall endpoint summary in IUCLID chapter 6.1, it can be concluded that tri-C9-11-alkyl esters (CAS No. 94279-36-4) is not expected to be acutely toxic to aquatic invertebrates.